MACROCYCLIC RENIN INHIBITORS - SYNTHESIS OF A SUBNANOMOLAR, ORALLY-ACTIVE CYSTEINE DERIVED INHIBITOR

被引：26

作者：

YANG, LH

WEBER, AE

GREENLEE, WJ

PATCHETT, AA

机构：

[1] Department of Exploratory Chemistry, Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(00)61590-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A class of novel thioether linked macrocyclic renin inhibitors was synthesized. A key element of the synthesis is the use of boroxazolidone for the simultaneous protection of the amino and carboxyl groups in L-cysteine.

引用

页码：7035 / 7038

页数：4

共 21 条

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