PEPTIDE NUCLEIC-ACID (PNA) - A MODEL STRUCTURE FOR THE PRIMORDIAL GENETIC MATERIAL

被引：117

作者：

NIELSEN, PE

机构：

[1] Research Center for Medical Biotechnology, Department of Biochemistry B, The Panum Institute, Copenhagen N, 2200

来源：

ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHERE | 1993年 / 23卷 / 5-6期

关键词：

D O I：

10.1007/BF01582083

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is proposed that the primordial genetic material could have been peptide nucleic acids, i.e., DNA analogues having a peptide backbone. PNA momomers based on the amino acid, alpha, gamma-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.

引用

页码：323 / 327

页数：5

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