NOVEL BIOPOLYMERS FOR DRUG DISCOVERY

被引：59

作者：

MORAN, EJ ^{[1
]}

WILSON, TE ^{[1
]}

CHO, CY ^{[1
]}

CHERRY, SR ^{[1
]}

SCHULTZ, PG ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

来源：

BIOPOLYMERS | 1995年 / 37卷 / 03期

关键词：

D O I：

10.1002/bip.360370305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The solid phase synthesis and generation of libraries of ''unnatural biopolymers'' is described. These polymers are characterized by novel backbones and building blocks, the properties of which may modify their pharmacological and folding properties (C) 1995 John Wiley & Sons, Inc.

引用

收藏

页码：213 / 219

页数：7

相关论文

共 55 条

[1] CYCLIC RGD PEPTIDE ANALOGS AS ANTIPLATELET ANTITHROMBOTICS [J].

BARKER, PL ;

BULLENS, S ;

BUNTING, S ;

BURDICK, DJ ;

CHAN, KS ;

DEISHER, T ;

EIGENBROT, C ;

GADEK, TR ;

GANTZOS, R ;

LIPARI, MT ;

MUIR, CD ;

NAPIER, MA ;

PITTI, RM ;

PADUA, A ;

QUAN, C ;

STANLEY, M ;

STRUBLE, M ;

TOM, JYK ;

BURNIER, JP .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (11) :2040-2048

[2]

BELL J, 1984, J PHARM PHARM S, V36, pP88

[3] EVALUATION OF PEPTIDE LIBRARIES - AN ITERATIVE STRATEGY TO ANALYZE THE REACTIVITY OF PEPTIDE MIXTURES WITH ANTIBODIES [J].

BLAKE, J ;

LITZIDAVIS, L .

BIOCONJUGATE CHEMISTRY, 1992, 3 (06) :510-513

[4] THE COMBINATORIAL SYNTHESIS AND CHEMICAL AND BIOLOGICAL EVALUATION OF A 1,4-BENZODIAZEPINE LIBRARY [J].

BUNIN, BA ;

PLUNKETT, MJ ;

ELLMAN, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4708-4712

[5] A GENERAL AND EXPEDIENT METHOD FOR THE SOLID-PHASE SYNTHESIS OF 1,4-BENZODIAZEPINE DERIVATIVES [J].

BUNIN, BA ;

ELLMAN, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) :10997-10998

[6] 9-FLUORENYLMETHOXYCARBONYL AMINO-PROTECTING GROUP [J].

CARPINO, LA ;

HAN, GY .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (22) :3404-&

[7] AN UNNATURAL BIOPOLYMER [J].

CHO, CY ;

MORAN, EJ ;

CHERRY, SR ;

STEPHANS, JC ;

FODOR, SPA ;

ADAMS, CL ;

SUNDARAM, A ;

JACOBS, JW ;

SCHULTZ, PG .

SCIENCE, 1993, 261 (5126) :1303-1305

[8] THE INFLUENCE OF PEPTIDE STRUCTURE ON TRANSPORT ACROSS CACO-2 CELLS .2. PEPTIDE-BOND MODIFICATION WHICH RESULTS IN IMPROVED PERMEABILITY [J].

CONRADI, RA ;

HILGERS, AR ;

HO, NFH ;

BURTON, PS .

PHARMACEUTICAL RESEARCH, 1992, 9 (03) :435-439

[9] DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY [J].

DEWITT, SH ;

KIELY, JS ;

STANKOVIC, CJ ;

SCHROEDER, MC ;

CODY, DMR ;

PAVIA, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :6909-6913

[10]

FAUCHERE JL, 1983, EUR J MED CHEM, V18, P369

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