THE USE OF HIV-1 PROTEASE STRUCTURE IN INHIBITOR DESIGN

被引：28

作者：

BABINE, RE

ZHANG, N

JURGENS, AR

SCHOW, SR

DESAI, PR

JAMES, JC

SEMMELHACK, MF

机构：

[1] Exploratory Medicinal Chemistry Section American Cyanamid Co. Medical Research Div. Lederle Labs. Pe

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81194-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The X-ray structure of HIV-1 protease and molecular dynamics studies were used in the design of pseudo-symmetrical enzyme inhibitors 1 and 2. Short bidirectional syntheses of these compounds are described.

引用

页码：541 / 546

页数：6

共 33 条

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