2 CHIRAL SYNTHESES OF THREO-3-HYDROXYLYSINE

被引:56
作者
HUGHES, PF
SMITH, SH
OLSON, JT
机构
[1] Sphinx Pharmaceuticals Inc., Five University Place, Durham
关键词
D O I
10.1021/jo00098a047
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two efficient chiral syntheses of 3-hydroxylysine, a naturally occurring amino acid and a putative intermediate in the synthesis of balanol, a potent protein kinase C inhibitor, are described. The synthesis of (2R,3S)-3-hydroxylysine utilizes Hayashi's chiral ferroceno gold catalyst. The synthesis of (2S,3R)-3-hydroxylysine demonstrates a beta-hydroxy amino acid synthesis with the chirality derived from the Sharpless chiral cis-hydroxylation.
引用
收藏
页码:5799 / 5802
页数:4
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