ENANTIOMERIC SEPARATION OF DINICONAZOLE AND UNICONAZOLE BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY

Enantiomeric separation of the structural analogues diniconazole and uniconazole by cyclodextrin (CD)-modified micellar electrokinetic chromatography was studied. The effects of the type of CDs, CD concentration and other operating parameters on the resolution of the enantiomers were clarified and the addition of an organic modifier to the separation solution was demonstrated to improve significantly the enantiomeric separation of both compounds. Enantiomeric separation of uniconazole was, in fact, achieved only with the addition of organic modifiers.