TRANSCRIPTION OF N-MYC AND PROLIFERATION-RELATED GENES IS LINKED IN HUMAN NEUROBLASTOMA

被引：19

作者：

RASCHELLA, G

NEGRONI, A

GIUBILEI, C

ROMEO, A

FERRARI, S

CASTELLO, MA

DOMINICI, C

机构：

[1] UNIV MODENA,CTR EXPTL HEMATOL,I-41100 MODENA,ITALY

[2] UNIV ROME LA SAPIENZA,DEPT PEDIAT,I-00161 ROME,ITALY

来源：

CANCER LETTERS | 1991年 / 56卷 / 01期

关键词：

NEUROBLASTOMA; N-MYC; HISTONE H3; CELL PROLIFERATION;

D O I：

10.1016/0304-3835(91)90192-K

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.

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页码：45 / 51

页数：7

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