SUBSTRATE-SPECIFICITY OF PROLINE 4-HYDROXYLASE - CHEMICAL AND ENZYMATIC-SYNTHESIS OF 2S,3R,4S-EPOXYPROLINE

被引：33

作者：

BALDWIN, JE ^{[1
]}

FIELD, RA ^{[1
]}

LAWRENCE, CC ^{[1
]}

LEE, V ^{[1
]}

ROBINSON, JK ^{[1
]}

SCHOFIELD, CJ ^{[1
]}

机构：

[1] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)60753-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The substrate specificity of L-proline 4-hydroxylase, a 2-oxoglutarate dependent dioxygenase from Streptomyces griseoviridus P8648, was investigated. Preliminary assays measuring turnover of 2-oxoglutarate indicated 3,4-dehydro-L-proline was an efficient substrate. The identity of the product was shown to be 2S,3R,4S-epoxy-L-proline by comparison with synthetic 2S,3R,4S- and 2S,3S,4R-epoxy-L-prolines.

引用

页码：4649 / 4652

页数：4

共 31 条

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