ALTERATIONS OF SEROTONIN RECEPTOR-BINDING IN THE HYPOTHALAMUS FOLLOWING ACUTE DENERVATION

被引:39
作者
FRANKFURT, M
MENDELSON, SD
MCKITTRICK, CR
MCEWEN, BS
机构
[1] The Rockefeller University, New York
关键词
SEROTONIN; 5,7-DIHYDROXYTRYPTAMINE; RECEPTOR; HYPOTHALAMUS; AUTORADIOGRAPHY;
D O I
10.1016/0006-8993(93)91735-B
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Quantitative autoradiography was used to determine the effect of acute serotonergic denervation with 5,7-dihydroxytryptamine (5,7-DHT) on serotonin 5HT1a and 5-HT1b receptors in male rats. Seven days after intrahypothalamic 5,7-DHT injection there was a significant increase in the density of 5HT1a receptors in the ventromedial and dorsomedial hypothalamic nuclei (VMN and DMN) of male rats. In adjacent sections, 5-HT1b receptors were significantly increased only in the VMN. No changes in receptor density were observed in the lateral hypothalamic area or hippocampus even though binding of [H-3]paroxetine, which labels the presynaptic transporter site, was significantly decreased in all evaluated brain regions in 5,7-DHT-treated animals. In addition to demonstrating that 5-HT1a and 5-HT1b receptors are differentially regulated in different brain areas, these results show that in the brain regions examined both 5-HT1a and 5-HT1b receptors are primarily post-synaptic.
引用
收藏
页码:349 / 352
页数:4
相关论文
共 24 条
[11]  
FRAZER A, 1990, ANNU REV PHARMACOL, V30, P307
[12]  
MELTZER HY, 1991, PHARMACOL REV, V43, P587
[13]   AUTORADIOGRAPHIC ANALYSES OF THE EFFECTS OF ESTRADIOL BENZOATE ON [H-3] PAROXETINE BINDING IN THE CEREBRAL-CORTEX AND DORSAL HIPPOCAMPUS OF GONADECTOMIZED MALE AND FEMALE RATS [J].
MENDELSON, SD ;
MCKITTRICK, CR ;
MCEWEN, BS .
BRAIN RESEARCH, 1993, 601 (1-2) :299-302
[14]   AUTORADIOGRAPHIC ANALYSES OF THE EFFECTS OF ADRENALECTOMY AND CORTICOSTERONE ON 5-HT1A AND 5-HT1B RECEPTORS IN THE DORSAL HIPPOCAMPUS AND CORTEX OF THE RAT [J].
MENDELSON, SD ;
MCEWEN, BS .
NEUROENDOCRINOLOGY, 1992, 55 (04) :444-450
[15]  
MORET C, 1985, NEUROPHARMACOLOGY SE, P21
[16]   UP-REGULATION OF SEROTONERGIC BINDING-SITES LABELED BY [H-3] WB4101 FOLLOWING FIMBRIAL TRANSECTION AND 5,7-DIHYDROXYTRYPTAMINE-INDUCED LESIONS [J].
MORROW, AL ;
NORMAN, AB ;
BATTAGLIA, G ;
LOY, R ;
CREESE, I .
LIFE SCIENCES, 1985, 37 (20) :1913-1922
[17]  
NELSON DL, 1978, MOL PHARMACOL, V14, P983
[18]   ORGANIZATION OF ASCENDING SEROTONIN SYSTEMS IN THE ADULT-RAT BRAIN - A AUTORADIOGRAPHIC STUDY AFTER INTRAVENTRICULAR ADMINISTRATION OF [5-HYDROXYTRYPTAMINE-H-3 [J].
PARENT, A ;
DESCARRIES, L ;
BEAUDET, A .
NEUROSCIENCE, 1981, 6 (02) :115-138
[19]   QUANTITATIVE AUTORADIOGRAPHIC MAPPING OF SEROTONIN RECEPTORS IN THE RAT-BRAIN .2. SEROTONIN-2 RECEPTORS [J].
PAZOS, A ;
CORTES, R ;
PALACIOS, JM .
BRAIN RESEARCH, 1985, 346 (02) :231-249
[20]   QUANTITATIVE AUTORADIOGRAPHIC MAPPING OF SEROTONIN RECEPTORS IN THE RAT-BRAIN .1. SEROTONIN-1 RECEPTORS [J].
PAZOS, A ;
PALACIOS, JM .
BRAIN RESEARCH, 1985, 346 (02) :205-230