Chromosomal localization of the human genes for alpha(1A), alpha(1B), and alpha(1E) voltage-dependent Ca2+ channel subunits

被引：67

作者：

Diriong, S

Lory, P

Williams, ME

Ellis, SB

Harpold, MM

Taviaux, S

机构：

[1] CNRS,CRBM,F-34033 MONTPELLIER,FRANCE

[2] INSERM,U249,F-34033 MONTPELLIER,FRANCE

[3] SALK INST BIOTECHNOL IND ASSOCIATES INC,LA JOLLA,CA 92037

来源：

GENOMICS | 1995年 / 30卷 / 03期

关键词：

D O I：

10.1006/geno.1995.1284

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The alpha(1) subunit genes encoding voltage-dependent Ca2+ channels are members of a gene family. We have used human brain cDNA probes to localize the neuronal isoform genes CACNL1A4 (alpha(1A)), CACNL1A5 (alpha(1B)), and CACNL1A6 (alpha(1E)) to 19p13, 9q34, and 1q25-q31, respectively, using fluorescence in situ hybridization on human chromosomes. These genes are particularly interesting gene candidates in the pathogenesis of neuronal disorders. Although genetic disorders have been linked to loci 9q34 and 19p13, no genetic disease related to Ca2+ signaling defects has yet been linked to these loci. (C) 1995 Academic Press, Inc.

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页码：605 / 609

页数：5

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