NGF INVOLVEMENT IN OCULAR INFLAMMATION - SECRETION BY RAT RESIDENT RETINAL CELLS

被引：15

作者：

DICOU, E ^{[1
]}

NERRIERE, V ^{[1
]}

NAUD, MC ^{[1
]}

DEKOZAK, Y ^{[1
]}

机构：

[1] INSERM,IMMUNOPATHOL OEIL LAB,U86,F-75270 PARIS 06,FRANCE

来源：

NEUROREPORT | 1994年 / 6卷 / 01期

关键词：

NERVE GROWTH FACTOR; RESIDENT RETINAL CELLS; AUTOIMMUNE UVEORETINITIS;

D O I：

10.1097/00001756-199412300-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NERVE growth factor (NGF) has been reported to be involved in immune and inflammatory reactions. We provide evidence that NGF may play a role in ocular immune responses. Experimental autoimmune uveoretinitis (EAU) causes ocular inflammation in susceptible (Lewis, Lew x Brown-Norway (BN) F-1 hybrid) but not in resistant or poorly susceptible BN and Long Evans rat strains. We examined NGF production by two resident ocular cell types, retinal Muller glia (RMG) and retinal pigmented epithelium (RPE). Interferon-gamma (IFN-gamma) or lipopolysaccharide (LPS) alone had no effect on NGF production while combined treatment with IFN-gamma and LPS strongly stimulated NGF secretion by both RMG and RPE cells. Furthermore, NGF secretion correlated with the degree of susceptibility to EAU of the different rat strains. RMG and RPE cells isolated from susceptible rats secrete high NGF levels while cells from resistant rats secrete low NGF levels.

引用

页码：26 / 28

页数：3

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