HIGH-DENSITY CELL-CULTURE BY MEMBRANE-BASED CELL RECYCLE

被引：56

作者：

CHANG, HN ^{[1
]}

YOO, IK ^{[1
]}

KIM, BS ^{[1
]}

机构：

[1] KOREA ADV INST SCI & TECHNOL, BIOPROC RES CTR, TAEJON 305701, SOUTH KOREA

来源：

BIOTECHNOLOGY ADVANCES | 1994年 / 12卷 / 03期

关键词：

HIGH DENSITY CELL CULTURE; CELL RECYCLE; CELL RETENTION; BIOREACTORS;

D O I：

10.1016/0734-9750(94)90020-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Enhancement of productivity of a bioprocess necessitates continuous operation of bioreactors with high biomass concentrations than are possible in conventional batch, fed-batch or continuous modes of culture. Membrane-based cell recycle has been effectively used to maintain high cell concentrations in bioreactors. This review compares membrane-based cell recycle operation with other such high density cell culture systems as immobilized cell reactors and reactors with cell recycle by centrifugation or gravity sedimentation. A theoretical of production of primary and secondary metabolites in membrane-based recycle systems is presented. Operation of this type of system is discussed with examples from aerobic and anaerobic fermentations.

引用

页码：467 / 487

页数：21

共 76 条

[1]

AFSCHAR AS, 1985, APPL MICROBIOL BIOT, V22, P394

[2] MICROFILTRATION CULTURE PROCESS FOR ENHANCED PRODUCTION OF RDNA RECEPTOR-CELLS OF ESCHERICHIA-COLI [J].

ANDERSON, KW ;

GRULKE, E ;

GERHARDT, P .

BIO-TECHNOLOGY, 1984, 2 (10) :891-896

[3]

BERG AC, 1989, APPL MICROBIOL BIOT, V30, P1

[4] HIGH-CONCENTRATION CULTIVATION OF LACTOCOCCUS-CREMORIS IN A CELL-RECYCLE REACTOR [J].

BIBAL, B ;

VAYSSIER, Y ;

GOMA, G ;

PAREILLEUX, A .

BIOTECHNOLOGY AND BIOENGINEERING, 1991, 37 (08) :746-754

[5] CONTINUOUS FERMENTATION OF SWEET WHEY PERMEATE FOR PROPIONIC-ACID PRODUCTION IN A CSTR WITH UF RECYCLE [J].

BOYAVAL, P ;

CORRE, C .

BIOTECHNOLOGY LETTERS, 1987, 9 (11) :801-806

[6] A STUDY OF CONTINUOUS ETHANOL-PRODUCTION USING A HIGHLY FLOCCULANT YEAST IN THE GAS LIFT TOWER FERMENTER [J].

BULOCK, JD ;

COMBERBACH, DM ;

GHOMMIDH, C .

CHEMICAL ENGINEERING JOURNAL AND THE BIOCHEMICAL ENGINEERING JOURNAL, 1984, 29 (01) :B9-B24

[7]

Chang H N, 1991, Adv Biochem Eng Biotechnol, V44, P27

[8]

CHANG HN, 1986, ACS SYM SER, V314, P32

[9]

CHANG HN, 1988, APPL MICROBIOL BIOT, V29, P107

[10] CELL RETENTION CULTURE WITH AN INTERNAL FILTER MODULE - CONTINUOUS ETHANOL FERMENTATION [J].

CHANG, HN ;

LEE, WG ;

KIM, BS .

BIOTECHNOLOGY AND BIOENGINEERING, 1993, 41 (06) :677-681

← 1 2 3 4 5 6 7 8 →