DISTINCT HEMODYNAMIC AND GASTRIC EFFECTS OF HUMAN CGRP-I AND CGRP-II IN MAN

被引：29

作者：

BEGLINGER, C

BORN, W

MUNCH, R

KURTZ, A

GUTZWILLER, JP

JAGER, K

FISCHER, JA

机构：

[1] UNIV BASEL HOSP,DEPT RES,DIV GASTROENTEROL,CH-4031 BASEL,SWITZERLAND

[2] UNIV ZURICH,DEPT MED,CH-8008 ZURICH,SWITZERLAND

[3] UNIV ZURICH,DEPT ORTHOPED SURG,CALCIUM METAB RES LAB,CH-8008 ZURICH,SWITZERLAND

[4] UNIV ZURICH,DEPT MED,DIV GASTROENTEROL,CH-8091 ZURICH,SWITZERLAND

[5] UNIV ZURICH,INST PHYSIOL,CH-8057 ZURICH,SWITZERLAND

[6] UNIV BASEL HOSP,DEPT RES,DIV ANGIOL,CH-4031 BASEL,SWITZERLAND

来源：

PEPTIDES | 1991年 / 12卷 / 06期

关键词：

ALDOSTERONE; CALCITONIN GENE-RELATED PEPTIDE; GASTRIC ACID SECRETION; RENIN ACTIVITY; VASODILATATION;

D O I：

10.1016/0196-9781(91)90218-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human calcitonin gene-related peptides I and II (or alpha and beta) (CGRP I and II) are encoded by two different genes, but they have 34 of the 37 amino acid residues in common. Human CGRP I more potently stimulated blood flow through the skin and carotid artery (p < 0.01), and the heart rate (p < 0.05), and plasma renin activity and aldosterone secretion than human CGRP II (p < 0.02). Inhibition of pentagastrin-stimulated gastric acid output, on the other hand, was only obtained with CGRP II. The separate effects of human CGRP I and II on the cardiovascular and gastric systems are presumably mediated by different receptors or receptor pathways recognized by the two closely related neuropeptides.

引用

页码：1347 / 1351

页数：5

共 35 条

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