N-METHYL-D-ASPARTATE RECEPTORS MODULATE EXTRACELLULAR 5-HYDROXYTRYPTAMINE CONCENTRATION IN RAT HIPPOCAMPUS AND STRIATUM IN-VIVO

被引:38
作者
WHITTON, PS
RICHARDS, DA
BIGGS, CS
FOWLER, LJ
机构
[1] Department of Pharmacology, School of Pharmacy, London, WC1N 1AX
关键词
N-METHYL-D-ASPARTATE; SEROTONIN; 5-HYDROXYINDOLEACETIC ACID; INTRACEREBRAL DIALYSIS;
D O I
10.1016/0304-3940(94)90395-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of infusing N-methyl-D-aspartate (NMDA) and the specific NMDA receptor antagonist D-2-amino-5-phosphonopropionic acid (D-AP5) into rat hippocampus and striatum on extracellular 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy-indoleacetic acid (5-HIAA) were studied using intracerebral microdialysis. In striatum, NMDA (1-100 muM) caused a concentration-dependent increase in 5-HT. D-AP5 (10 muM) infusion caused increased extracellular 5-HT. When the two drugs were co-infused, no effect on extracellular 5-HT was seen. D-AP5 alone was found to cause a delayed but sustained increase in dialysate 5-HIAA. In hippocampus, NMDA infusion caused a dose-dependent decrease in extracellular 5-HT while D-AP5 produced a transitory increase in 5-HT level. NMDA caused a decrease in dialysate 5-HIAA. In striatum, the effect of 10 muM NMDA infusion was abolished by co-infusion with tetrodotoxin (TTX; 1 muM). In hippocampus, 1 muM TTX caused a slight but non-significant augmentation of the effect of 10 muM NMDA alone. These data indicate that NMDA receptors mediate control over 5-HT release and metabolism in different brain regions and may in part explain the behavioural effects of non-competitive NMDA receptor antagonists.
引用
收藏
页码:215 / 218
页数:4
相关论文
共 9 条
[1]   INVIVO EVIDENCE FOR AN INHIBITORY GLUTAMATERGIC CONTROL OF SEROTONIN RELEASE IN THE CAT CAUDATE-NUCLEUS - INVOLVEMENT OF GABA NEURONS [J].
BECQUET, D ;
FAUDON, M ;
HERY, F .
BRAIN RESEARCH, 1990, 519 (1-2) :82-88
[2]   NMDA RECEPTORS AND INVIVO DOPAMINE RELEASE IN THE NUCLEUS-ACCUMBENS AND NUCLEUS-CAUDATUS [J].
IMPERATO, A ;
SCROCCO, MG ;
BACCHI, S ;
ANGELUCCI, L .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (03) :555-556
[3]   THE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST MK-801 INDUCES INCREASES IN DOPAMINE AND SEROTONIN METABOLISM IN SEVERAL BRAIN-REGIONS OF RATS [J].
LOSCHER, W ;
ANNIES, R ;
HONACK, D .
NEUROSCIENCE LETTERS, 1991, 128 (02) :191-194
[4]  
LOSCHER W, 1991, J PHARMACOL EXP THER, V256, P430
[5]  
Paxinos G., 2007, RAT BRAIN STEROTAXIC
[6]   THE BEHAVIORAL-EFFECTS OF MK-801 - A COMPARISON WITH ANTAGONISTS ACTING NON-COMPETITIVELY AND COMPETITIVELY AT THE NMDA RECEPTOR [J].
TRICKLEBANK, MD ;
SINGH, L ;
OLES, RJ ;
PRESTON, C ;
IVERSEN, SD .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 167 (01) :127-135
[7]  
TRICKLEBANK MD, 1985, EUROPEAN J PHARM, V106, P271
[8]   THE EFFECT OF VALPROIC ACID ON 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID CONCENTRATION IN HIPPOCAMPAL DIALYSATES INVIVO [J].
WHITTON, PS ;
FOWLER, LJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 200 (01) :167-169
[9]   MK-801 INCREASES EXTRACELLULAR 5-HYDROXYTRYPTAMINE IN RAT HIPPOCAMPUS AND STRIATUM INVIVO [J].
WHITTON, PS ;
BIGGS, CS ;
PEARCE, BR ;
FOWLER, LJ .
JOURNAL OF NEUROCHEMISTRY, 1992, 58 (04) :1573-1575