ELECTROSTATIC COMPLEMENTARITY WITHIN THE SUBSTRATE-BINDING POCKET OF TRYPSIN

被引：173

作者：

GRAF, L

JANCSO, A

SZILAGYI, L

HEGYI, G

PINTER, K

NARAYSZABO, G

HEPP, J

MEDZIHRADSZKY, K

RUTTER, WJ

机构：

[1] CHINOIN PHARMACEUT & CHEM WORKS,H-1325 BUDAPEST,HUNGARY

[2] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1025 BUDAPEST,HUNGARY

[3] UNIV CALIF SAN FRANCISCO,HORMONE RES INST,SAN FRANCISCO,CA 94143

[4] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1988年 / 85卷 / 14期

关键词：

D O I：

10.1073/pnas.85.14.4961

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

收藏

页码：4961 / 4965

页数：5

相关论文

共 25 条

[1] STRUCTURE AND MECHANISM OF CHYMOTRYPSIN
BLOW, DM
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1976, 9 (04) : 145 - 152
[2] REFINED CRYSTAL-STRUCTURE OF BOVINE BETA-TRYPSIN AT 1.8 A RESOLUTION .2. CRYSTALLOGRAPHIC REFINEMENT, CALCIUM-BINDING SITE, BENZAMIDINE BINDING-SITE AND ACTIVE-SITE AT PH 7.0
BODE, W
SCHWAGER, P
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (04) : 693 - 717
[3] BODE W, 1975, ENZYMES ELECTRON TRA, P3
[4] THE CATALYTIC ROLE OF THE ACTIVE-SITE ASPARTIC-ACID IN SERINE PROTEASES
CRAIK, CS
ROCZNIAK, S
LARGMAN, C
RUTTER, WJ
[J]. SCIENCE, 1987, 237 (4817) : 909 - 913
[5] CRAIK CS, 1984, J BIOL CHEM, V259, P4255
[6] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING
FERSHT, AR
SHI, JP
KNILLJONES, J
LOWE, DM
WILKINSON, AJ
BLOW, DM
BRICK, P
CARTER, P
WAYE, MMY
WINTER, G
[J]. NATURE, 1985, 314 (6008) : 235 - 238
[7] CONFORMATIONAL EQUILIBRIA IN ALPHA-CHYMOTRYPSIN AND DELTA-CHYMOTRYPSIN - ENERGETICS AND IMPORTANCE OF SALT BRIDGE
FERSHT, AR
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1972, 64 (02) : 497 - &
[8] SELECTIVE ALTERATION OF SUBSTRATE-SPECIFICITY BY REPLACEMENT OF ASPARTIC ACID-189 WITH LYSINE IN THE BINDING POCKET OF TRYPSIN
GRAF, L
CRAIK, CS
PATTHY, A
ROCZNIAK, S
FLETTERICK, RJ
RUTTER, WJ
[J]. BIOCHEMISTRY, 1987, 26 (09) : 2616 - 2623
[9] HENKEL JG, 1985, MOL GRAPHICS IBM PC
[10] STRUCTURAL BASIS OF ACTIVATION AND ACTION OF TRYPSIN
HUBER, R
BODE, W
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1978, 11 (03) : 114 - 122