TOTAL SYNTHESIS AND TREHALASE-INHIBITORY ACTIVITY OF TREHALOSTATIN AND ITS DIASTEREOISOMER

被引:12
作者
UCHIDA, C [1 ]
YAMAGISHI, T [1 ]
OGAWA, S [1 ]
机构
[1] KEIO UNIV, FAC SCI & TECHNOL, DEPT APPL CHEM, YOKOHAMA, KANAGAWA 223, JAPAN
关键词
D O I
10.1246/cl.1993.971
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Complete synthesis of both diastereoisomeric structures, initially proposed for the trehalase inhibitor trehalostatin, and their biological assay have been carried out. The synthetic compounds were found to lack an inhibitory activity against trehalase, suggesting that the inhibitor would possess convincingly its 4'-epimeric structure later assigned for trehazolin.
引用
收藏
页码:971 / 974
页数:4
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