Total synthesis of natural (-)-combretastatin D-1.

被引：20

作者：

Couladouros, EA

Soufli, IC

机构：

[1] Department of Chemistry, Agricultural University of Athens, Athens, 118.55

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

关键词：

D O I：

10.1016/0040-4039(95)01987-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Combrestastatin D-1, (2), was synthesized via a 12 step sequence. Sharpless asymmetric dihydroxylation was used in order to introduce the appropriate asymmetry. Regiospecific cyclodehydration of the diol 3 gave the title compound in 96% ee.

引用

页码：9369 / 9372

页数：4

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