SYNTHESIS OF OPTICALLY-ACTIVE CYANOHYDRINS USING ALMOND MEAL

被引：95

作者：

ZANDBERGEN, P ^{[1
]}

VANDERLINDEN, J ^{[1
]}

BRUSSEE, J ^{[1
]}

VANDERGEN, A ^{[1
]}

机构：

[1] LEIDEN UNIV,GORLAEUS LABS,DEPT CHEM,POB 9502,2300 RA LEIDEN,NETHERLANDS

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 12-13期

关键词：

D O I：

10.1080/00397919108021286

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric hydrocyanation of aldehydes was accomplished using almond meal, containing the enzyme oxynitrilase. Optically active cyanohydrins with high levels of enantiomeric purity were obtained following a simple procedure.

引用

页码：1387 / 1391

页数：5

共 11 条

[1] SYNTHESIS OF OPTICALLY-ACTIVE SILYL PROTECTED CYANOHYDRINS [J].

BRUSSEE, J ;

LOOS, WT ;

KRUSE, CG ;

VANDERGEN, A .

TETRAHEDRON, 1990, 46 (03) :979-986

[2] BIO-ORGANIC SYNTHESIS OF OPTICALLY-ACTIVE CYANOHYDRINS AND ACYLOINS [J].

BRUSSEE, J ;

ROOS, EC ;

VANDERGEN, A .

TETRAHEDRON LETTERS, 1988, 29 (35) :4485-4488

[3]

BRUSSEE J, 1991, RECL TRAV CHIM PAY B, V110, P25

[4] SYNTHESIS OF OPTICALLY-ACTIVE ETHANOLAMINES [J].

BRUSSEE, J ;

DOFFERHOFF, F ;

KRUSE, CG ;

VANDERGEN, A .

TETRAHEDRON, 1990, 46 (05) :1653-1658

[5] ENZYME-CATALYZED CYANOHYDRIN SYNTHESIS IN ORGANIC-SOLVENTS [J].

EFFENBERGER, F ;

ZIEGLER, T ;

FORSTER, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1987, 26 (05) :458-460

[6]

HORWITZ W, 1980, OFFICIAL METHODS ANA, P318

[7] THE ASYMMETRIC HYDROCYANATION OF ALDEHYDES WITH CYANOTRIMETHYLSILANE PROMOTED BY A CHIRAL TITANIUM REAGENT [J].

NARASAKA, K ;

YAMADA, T ;

MINAMIKAWA, H .

CHEMISTRY LETTERS, 1987, (10) :2073-2076

[8] ENZYME-CATALYZED SYNTHESIS OF (S)-CYANOHYDRINS [J].

NIEDERMEYER, U ;

KULA, MR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1990, 29 (04) :386-387

[9] ASYMMETRIC CYANOHYDRIN SYNTHESIS CATALYZED BY A SYNTHETIC CYCLIC DIPEPTIDE [J].

OKU, JI ;

INOUE, S .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (05) :229-230

[10] CHIRAL LEWIS-ACIDS FOR ENANTIOSELECTIVE C-C BOND FORMATION [J].

REETZ, MT ;

KUNISCH, F ;

HEITMANN, P .

TETRAHEDRON LETTERS, 1986, 27 (39) :4721-4724

← 1 2 →