ALPHA-TOCOPHEROL MEDIATED PEROXIDATION IN THE COPPER(II) AND MET MYOGLOBIN INDUCED OXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN - THE INFLUENCE OF LIPID HYDROPEROXIDES

被引：38

作者：

IWATSUKI, M

NIKI, E

STONE, D

DARLEYUSMAR, VM

机构：

[1] WELLCOME RES LABS, DEPT BIOCHEM SCI, BECKENHAM BR3 3BS, KENT, ENGLAND

[2] UNIV TOKYO, ADV SCI & TECHNOL RES CTR, TOKYO 153, JAPAN

来源：

FEBS LETTERS | 1995年 / 360卷 / 03期

关键词：

LIPID PEROXIDATION; MYOGLOBIN; ALPHA-TOCOPHEROL; LIPID PEROXIDE; ATHEROSCLEROSIS; LOW DENSITY LIPOPROTEIN;

D O I：

10.1016/0014-5793(95)00122-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The principal antioxidant in human LDL, alpha-tocopherol, is converted to the alpha-tocopheroxyl radical after reaction,vith peroxyl radicals or Cu2+, and, if it does not terminate with peroxyl radicals, could initiate lipid peroxidation; a phenomenon called 'tocopherol mediated peroxidation'. Only in the presence of Cu2+ and low levels of lipid hydroperoxides was an alpha-tocopherol dependent decrease in the resistance of LDL to oxidation detected. This suggests that tocopherol mediated peroxidation will probably not contribute significantly as a pro-oxidant process in those individuals most at risk of developing atherosclerosis through an oxidative mechanism.

引用

收藏

页码：271 / 276

页数：6

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