PROTONATION STATES OF THE CATALYTIC INTERMEDIATES OF CYTOCHROME-C-OXIDASE

被引：77

作者：

MITCHELL, R ^{[1
]}

MITCHELL, P ^{[1
]}

RICH, PR ^{[1
]}

机构：

[1] GLYNN RES INST,BODMIN PL30 4AU,CORNWALL,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1101卷 / 02期

基金：

英国惠康基金;

关键词：

CYTOCHROME C-OXIDASE; P-STATE; F-STATE; PROTONATION CHANGE;

D O I：

10.1016/S0005-2728(05)80016-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protonation changes accompanying conversion of oxidised (O state) cytochrome c oxidase to the 2-electron-reduced P state, and 3-electron-reduced F state at pH 8.0 have been measured. It was found that 2 and 3 protons, respectively, were taken up. The fourth proton required for the reduction of O2 to H2O must therefore be consumed in the remaining F --> O portion of the catalytic cycle.

引用

页码：188 / 191

页数：4

共 11 条

[1]

BICKAR D, 1984, J BIOL CHEM, V259, P777

[2]

BLAIR DF, 1986, J BIOL CHEM, V261, P1524

[3] FERRYL AND HYDROXY INTERMEDIATES IN THE REACTION OF OXYGEN WITH REDUCED CYTOCHROME-C-OXIDASE [J].