GENETIC AND ENVIRONMENTAL ASPECTS OF THE ROLE OF NICOTINIC RECEPTORS IN NEURODEGENERATIVE DISORDERS - EMPHASIS ON ALZHEIMERS-DISEASE AND PARKINSONS-DISEASE

被引：76

作者：

JAMES, JR ^{[1
]}

NORDBERG, A ^{[1
]}

机构：

[1] KAROLINSKA INST, HUDDINGE UNIV HOSP, DEPT CLIN NEUROSCI & FAMILY MED, DIV NICOTINE RES, S-14186 HUDDINGE, SWEDEN

来源：

BEHAVIOR GENETICS | 1995年 / 25卷 / 02期

关键词：

NICOTINIC RECEPTORS; ALZHEIMERS DISEASE; PARKINSONS DISEASE; GENETICS; ENVIRONMENTAL; NEUROPROTECTIVE;

D O I：

10.1007/BF02196924

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

As neurodegenerative disorders are better characterized, the importance of genetic and environmental interactions is becoming more evident. Among the neurodegenerative disorders, Alzheimer's disease and Parkinson's disease are both characterized by large losses of nicotinic binding sites in brain. In addition, losses in nicotinic receptors occur during normal aging. Chronic administration of nicotine in man or experimental animals increases the number of nicotinic receptors in brain. Nicotine has been shown to possess some neuroprotective properties for both cholinergic and dopaminergic neurons. These neuroprotective properties, when better understood, may provide important information on normal aging and neurodegenerative disorder related neuronal cell death. Understanding the functional aspects of neuronal nicotinic receptor subtypes may lead to successful therapeutic treatments or disease preventative strategies for neurodegenerative disorders.

引用

页码：149 / 159

页数：11

共 131 条

[91]

NYBACK H, 1989, PROG BRAIN RES, V79, P313

[92] DESENSITIZATION OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR - MOLECULAR MECHANISMS AND EFFECT OF MODULATORS [J].