RELATION BETWEEN LOW CAPACITY OF HUMAN SERA TO INHIBIT STREPTOCOCCAL MITOGENS AND SERIOUS MANIFESTATION OF DISEASE

被引：83

作者：

NORRBYTEGLUND, A ^{[1
]}

PAUKSENS, K ^{[1
]}

HOLM, SE ^{[1
]}

NORGREN, M ^{[1
]}

机构：

[1] AKAD SJUKHUSET UPPSALA,DEPT INFECT DIS,UPPSALA,SWEDEN

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 03期

关键词：

D O I：

10.1093/infdis/170.3.585

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The proliferative response of lymphocytes induced by a new streptococcal mitogenic factor (MF) and the streptococcal pyrogenic exotoxins (Spe) A and B was determined in sera from 6 healthy persons. Responses were compared to those obtained from reference serum that lacked mitogen-specific ELISA antibodies. The sera showed individual variations in the levels of MF-and Spe-specific antibodies, as determined by ELISA. The experiments showed that most human sera, which contained mitogen-specific antibodies, could neutralize the mitogenicity of the proteins. However, there were sera that contained mitogen-specific antibodies but that did not inhibit the toxin-induced proliferation. Thus, the ELISA antibody titer did not always equal the neutralizing capacity. Sera from 27 patients with group A streptococcal bacteremia had significantly lower neutralizing ability against MF and SpeB than did sera from 25 uncomplicated tonsillitis cases.

引用

页码：585 / 591

页数：7

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