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OXIDATION OF LOW-DENSITY LIPOPROTEINS - QUESTIONS OF INITIATION, PROPAGATION, AND THE EFFECT OF ANTIOXIDANTS

被引：79
作者：
HALLIWELL, B
机构：
[1] Pharmacology Group, King's College, London
[2] Pharmacology Group, King's College, London SW3 6LX, Manresa Road
来源：
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1995年 / 61卷 / 03期
关键词：
LOW-DENSITY LIPOPROTEIN; COPPER; LIPID PEROXIDATION; ALPHA-TOCOPHEROL; NITRIC OXIDE;
D O I：
10.1093/ajcn/61.3.670S
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Oxidation of low-density lipoproteins (LDLs) plays a role in the development of atherosclerosis, but many questions remain unanswered. This paper aims to evaluate critically the available data pertinent to the following questions: 1) How is LDL oxidation initiated, especially in early atherosclerotic lesions? 2) Is nitric oxide good or bad in lesions? and 3) Which antioxidants are really important in protecting LDLs against oxidation in the human body?
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页码：670S / 677S
页数：8
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