ASSIGNMENT OF THE GENE FOR BETA-SPECTRIN (SPTB) TO CHROMOSOME-14Q23-]Q24.2 BY INSITU HYBRIDIZATION

被引：27

作者：

FUKUSHIMA, Y

BYERS, MG

WATKINS, PC

WINKELMANN, JC

FORGET, BG

SHOWS, TB

机构：

[1] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT HUMAN GENET,666 ELM ST,BUFFALO,NY 14263

[2] YALE UNIV,SCH MED,DEPT MED,NEW HAVEN,CT 06510

[3] LIFE TECHNOL,GAITHERSBURG,MD

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 53卷 / 04期

关键词：

D O I：

10.1159/000132939

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Type I hereditary spherocytosis results from a molecular defect in the β-polypeptide of the erythrocyte cytoskeletal protein spectrin. Using a cDNA probe, we had previously assigned the gene for human erythrocyte P-spectrin (SPTB) to chromosome 14 based upon analysis of its segregation in panels of human x rodent somatic cell hybrids (Winkelmann et al., 1988). Here we report the regional localization of this gene by in situ hybridization to 14q23→q24.2. © 1990 S. Karger AG, Basel.

引用

页码：232 / 233

页数：2

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