FATE AND MICROBIOLOGICAL EFFECTS OF FURAZOLIDONE IN A MARINE AQUACULTURE SEDIMENT

被引:33
作者
SAMUELSEN, OB [1 ]
SOLHEIM, E [1 ]
LUNESTAD, BT [1 ]
机构
[1] UNIV BERGEN,DEPT MICROBIOL & PLANT PHYSIOL,N-5007 BERGEN,NORWAY
关键词
D O I
10.1016/0048-9697(91)90364-K
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Furazolidone is used in the treatment of bacterial diseases in farmed fish. During application a large proportion of the administered drug reaches the environment directly or via feces. The persistence and metabolism of furazolidone in sediment from a Norwegian salmon farm is described. Furazolidone, in contrast to oxytetracycline and oxolinic acid, is actively metabolized by microorganisms in the sediment. The main metabolite is 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone. This is a well known metabolite of the degradation of furazolidone in mammals, fish and Escherichia coli. 3-(4-Cyano-2-oxobutylideneamino)-2-oxazolidone had no detectable antibacterial activity. The half-life of furazolidone in the sediment at 4-degrees-C was calculated to be 18 h.
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页码:275 / 283
页数:9
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