FATE AND MICROBIOLOGICAL EFFECTS OF FURAZOLIDONE IN A MARINE AQUACULTURE SEDIMENT

被引：33

作者：

SAMUELSEN, OB ^{[1
]}

SOLHEIM, E ^{[1
]}

LUNESTAD, BT ^{[1
]}

机构：

[1] UNIV BERGEN,DEPT MICROBIOL & PLANT PHYSIOL,N-5007 BERGEN,NORWAY

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 1991年 / 108卷 / 03期

关键词：

D O I：

10.1016/0048-9697(91)90364-K

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Furazolidone is used in the treatment of bacterial diseases in farmed fish. During application a large proportion of the administered drug reaches the environment directly or via feces. The persistence and metabolism of furazolidone in sediment from a Norwegian salmon farm is described. Furazolidone, in contrast to oxytetracycline and oxolinic acid, is actively metabolized by microorganisms in the sediment. The main metabolite is 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone. This is a well known metabolite of the degradation of furazolidone in mammals, fish and Escherichia coli. 3-(4-Cyano-2-oxobutylideneamino)-2-oxazolidone had no detectable antibacterial activity. The half-life of furazolidone in the sediment at 4-degrees-C was calculated to be 18 h.

引用

页码：275 / 283

页数：9

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