PHOTOINDUCED DNA CLEAVAGE BY DESIGNED MOLECULES WITH CONJUGATED ENE-YNE-KETENE FUNCTIONALITIES

被引：54

作者：

NAKATANI, K ^{[1
]}

ISOE, S ^{[1
]}

MAEKAWA, S ^{[1
]}

SAITO, I ^{[1
]}

机构：

[1] OSAKA CITY UNIV,FAC SCI,INST ORGAN CHEM,SUMIYOSI,OSAKA 558,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 04期

关键词：

DNA CLEAVAGE; ENE-YNE-KETENE; DIAZOKETONE; NEOCARZINOSTATIN MODEL;

D O I：

10.1016/S0040-4039(00)75850-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Upon photoirradiation, diazoketone 1 was found to induce single strand cleavage of plasmid pBR322 DNA at concentration of 100 mu M. Conjugate ene-yne moiety was essential for DNA-cleaving activities.

引用

页码：605 / 608

页数：4

共 15 条

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