C2,N6-DISUBSTITUTED ADENOSINES - SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIPS

被引：33

作者：

TRIVEDI, BK ^{[1
]}

BRUNS, RF ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES DIV,DEPT PHARMACOL,ANN ARBOR,MI 48105

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 08期

关键词：

D O I：

10.1021/jm00128a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1667 / 1673

页数：7

共 17 条

[1] N6-[2-(3,5-DIMETHOXYPHENYL)-2-(2-METHYLPHENYL)ETHYL]ADENOSINE AND ITS URONAMIDE DERIVATIVES - NOVEL ADENOSINE AGONISTS WITH BOTH HIGH-AFFINITY AND HIGH SELECTIVITY FOR THE ADENOSINE A2-RECEPTOR [J].

BRIDGES, AJ ;

BRUNS, RF ;

ORTWINE, DF ;

PRIEBE, SR ;

SZOTEK, DL ;

TRIVEDI, BK .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (07) :1282-1285

[2] N-6-(2,2-DIPHENYLETHYL)ADENOSINE, A NOVEL ADENOSINE RECEPTOR AGONIST WITH ANTIPSYCHOTIC-LIKE ACTIVITY [J].

BRIDGES, AJ ;

MOOS, WH ;

SZOTEK, DL ;

TRIVEDI, BK ;

BRISTOL, JA ;

HEFFNER, TG ;

BRUNS, RF ;

DOWNS, DA .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (10) :1709-1711

[3]

BRUNS RF, 1986, MOL PHARMACOL, V29, P331

[4] STRUCTURE-ACTIVITY-RELATIONSHIPS FOR N6-SUBSTITUTED ADENOSINES AT A BRAIN ADENOSINE-A1-RECEPTOR WITH A COMPARISON TO AN ADENOSINE-A2 RECEPTOR REGULATING CORONARY BLOOD-FLOW [J].

DALY, JW ;

PADGETT, W ;

THOMPSON, RD ;

KUSACHI, S ;

BUGNI, WJ ;

OLSSON, RA .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (15) :2467-2481

[5] CORRELATION OF ADENOSINE RECEPTOR AFFINITIES AND CARDIOVASCULAR ACTIVITY [J].

HAMILTON, HW ;

TAYLOR, MD ;

STEFFEN, RP ;

HALEEN, SJ ;

BRUNS, RF .

LIFE SCIENCES, 1987, 41 (20) :2295-2302

[6] NOMENCLATURE OF ADENOSINE RECEPTORS [J].

HAMPRECHT, B ;

VANCALKER, D .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1985, 6 (04) :153-154

[7] SUBCLASSES OF EXTERNAL ADENOSINE RECEPTORS [J].

LONDOS, C ;

COOPER, DMF ;

WOLFF, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (05) :2551-2554

[8]

MARUMOTO R, 1975, CHEM PHARM BULL, V23, P759

[9] N6-CYCLOALKYLADENOSINES - POTENT, A1-SELECTIVE ADENOSINE AGONISTS [J].

MOOS, WH ;

SZOTEK, DS ;

BRUNS, RF .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (10) :1383-1384

[10] N-6-SUBSTITUTED N-ALKYLADENOSINE-5'-URONAMIDES - BIFUNCTIONAL LIGANDS HAVING RECOGNITION GROUPS FOR A1 AND A2 ADENOSINE RECEPTORS [J].

OLSSON, RA ;

KUSACHI, S ;

THOMPSON, RD ;

UKENA, D ;

PADGETT, W ;

DALY, JW .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (09) :1683-1689

← 1 2 →