PAPAIN-CATALYZED SYNTHESIS OF PEPTIDE ISOSTERES

被引：15

作者：

SCHUSTER, M ^{[1
]}

MUNOZ, B ^{[1
]}

YUAN, W ^{[1
]}

WONG, CH ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CHEM, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 08期

关键词：

PEPTIDE ISOSTERE; ENZYMATIC SYNTHESIS; PROTEASE; ACYL TRANSFER;

D O I：

10.1016/S0040-4039(00)91765-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The thiol protease papain catalyses the transfer of the Cbz-Gly moiety from the donor substrate Cbz-Gly-OMe to the amino group of various alpha-hydroxy- and alpha-keto-amines, providing a new route to peptide isosteres.

引用

页码：1247 / 1250

页数：4

共 14 条

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[9]

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[10]

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