EXPRESSION OF CYTOCHROME-P450 MESSENGER-RNAS IN THE COLON AND THE RECTUM IN NORMAL HUMAN-SUBJECTS

被引:34
作者
MERCURIO, MG [1 ]
SHIFF, SJ [1 ]
GALBRAITH, RA [1 ]
SASSA, S [1 ]
机构
[1] ROCKEFELLER UNIV, BIOCHEM HEMATOL LAB, NEW YORK, NY 10021 USA
关键词
D O I
10.1006/bbrc.1995.1668
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The expression of mRNA for three isozymes of cytochrome P450, CYP1A1, 1A2 and 3A3, was examined in biopsied samples of colon and rectum from five healthy subjects. Using RT-PCR, it was possible to detect the three CYP mRNA species at both sites in all samples examined. The expression of each CYP mRNA was site-specific in that rectum had higher levels of CYP1A1 mRNA than colon, while colon had higher levels of CYP3A3 mRNA than in rectum. In contrast, there was no consistent trend in CYP1A2 mRNA expression between the two sites. Variability of alimentary CYP expression may contribute to individual differences in susceptibility to carcinogens and/or drugs. (C) 1995 Academic Press, Inc.
引用
收藏
页码:350 / 355
页数:6
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