A D-1 AGONIST IN THE MPOA FACILITATES COPULATION IN MALE-RATS

被引：60

作者：

MARKOWSKI, VP ^{[1
]}

EATON, RC ^{[1
]}

LUMLEY, LA ^{[1
]}

MOSES, J ^{[1
]}

HULL, EM ^{[1
]}

机构：

[1] SUNY BUFFALO,DEPT PSYCHOL,BUFFALO,NY 14260

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 47卷 / 03期

关键词：

DIHYDROXYPHENYL-TETRAHYDROTHIENOPYRIDINE (THP); DOPAMINE D-1 RECEPTOR; COPULATION; MEDIAL PREOPTIC AREA;

D O I：

10.1016/0091-3057(94)90147-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The classic dopamine agonist apomorphine, microinjected into the medial preoptic area (MPOA), enhances the copulatory behavior of male rats, while pharmacological blockade of endogenous dopamine inhibits sexual behavior. We now report that MPOA injections of 10 mu g of the selective D-1 agonist dihydroxyphenyl-tetrahydrothienopyridine (THP) significantly increased the number of ejaculations, while decreasing the latency to ejaculate in a 30-min test. These effects were not observed following coadministration of the selective D-1 antagonist SCH-23390 with 10 mu g THP. This enhancement may be related to a D-1-stimulated facilitation of penile erections.

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页码：483 / 486

页数：4

相关论文

共 23 条

[1] DOSE DEPENDENT D2 EFFECTS ON GENITAL REFLEXES AFTER MPOA INJECTIONS OF QUINELORANE AND APOMORPHINE [J].

BAZZETT, TJ ;

EATON, RC ;

THOMPSON, JT ;

MARKOWSKI, VP ;

LUMLEY, LA ;

HULL, EM .

LIFE SCIENCES, 1991, 48 (24) :2309-2315

[2] INHIBITION BY DOPAMINE OF (NA++K+)ATPASE ACTIVITY IN NEOSTRIATAL NEURONS THROUGH D1 AND D2 DOPAMINE RECEPTOR SYNERGISM [J].

BERTORELLO, AM ;

HOPFIELD, JF ;

APERIA, A ;

GREENGARD, P .

NATURE, 1990, 347 (6291) :386-388

[3] PHARMACOLOGICAL ANALYSIS OF MALE-RAT SEXUAL-BEHAVIOR [J].

BITRAN, D ;

HULL, EM .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1987, 11 (04) :365-389

[4] DOPAMINE FUNCTIONS IN APPETITIVE AND DEFENSIVE BEHAVIORS [J].

BLACKBURN, JR ;

PFAUS, JG ;

PHILLIPS, AG .

PROGRESS IN NEUROBIOLOGY, 1992, 39 (03) :247-279

[5] OBLIGATORY D-1 D-2 RECEPTOR INTERACTION IN THE GENERATION OF DOPAMINE AGONIST RELATED BEHAVIORS [J].

BRAUN, AR ;

CHASE, TN .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 131 (2-3) :301-306

[6] REVIEW - D1 DOPAMINE RECEPTOR - THE SEARCH FOR A FUNCTION - A CRITICAL-EVALUATION OF THE D1/D2 DOPAMINE RECEPTOR CLASSIFICATION AND ITS FUNCTIONAL IMPLICATIONS [J].

CLARK, D ;

WHITE, FJ .

SYNAPSE, 1987, 1 (04) :347-388

[7]

HUANG KX, 1992, ABSTR SOC NEUROSCI, V18, P276

[8] DOPAMINERGIC CONTROL OF MALE SEX BEHAVIOR IN RATS - EFFECTS OF AN INTRACEREBRALLY-INFUSED AGONIST [J].

HULL, EM ;

BITRAN, D ;

PEHEK, EA ;

WARNER, RK ;

BAND, LC ;

HOLMES, GM .

BRAIN RESEARCH, 1986, 370 (01) :73-81

[9] COPULATION INCREASES DOPAMINE ACTIVITY IN THE MEDIAL PREOPTIC AREA OF MALE-RATS [J].

HULL, EM ;

EATON, RC ;

MOSES, J ;

LORRAIN, D .

LIFE SCIENCES, 1993, 52 (11) :935-940

[10] OPPOSITE INFLUENCE OF MEDIAL PREOPTIC D1 AND D2 RECEPTORS ON GENITAL REFLEXES - IMPLICATIONS FOR COPULATION [J].

HULL, EM ;

EATON, RC ;

MARKOWSKI, VP ;

MOSES, J ;

LUMLEY, LA ;

LOUCKS, JA .

LIFE SCIENCES, 1992, 51 (22) :1705-1713