EFFECT OF FLUVOXAMINE ON THE PHARMACOKINETICS OF IMIPRAMINE AND DESIPRAMINE IN HEALTHY-SUBJECTS

被引：111

作者：

SPINA, E ^{[1
]}

POLLICINO, AM ^{[1
]}

AVENOSO, A ^{[1
]}

CAMPO, GM ^{[1
]}

PERUCCA, E ^{[1
]}

CAPUTI, AP ^{[1
]}

机构：

[1] UNIV PAVIA,CLIN PHARMACOL UNIT,I-27100 PAVIA,ITALY

来源：

THERAPEUTIC DRUG MONITORING | 1993年 / 15卷 / 03期

关键词：

FLUVOXAMINE; IMIPRAMINE; DESIPRAMINE; DRUG INTERACTION; DEMETHYLATION; HYDROXYLATION;

D O I：

10.1097/00007691-199306000-00011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The effect of the selective serotonin reuptake inhibitor fluvoxamine (100 mg/day for 10 consecutive days) on the kinetics of a single oral dose of imipramine (50 mg) and desipramine (100 mg) was investigated in 12 healthy subjects. Compared with a control session, treatment with fluvoxamine caused a significant prolongation of imipramine half-life (from 22.8 +/- 6.4 to 40.5 +/- 5.0 h, means +/- SD, p < 0.01) and a marked decrease in imipramine apparent oral clearance (from 1.02 +/- 0.19 to 0.28 +/- 0.06 L/h/kg, p < 0.0001). No significant changes in desipramine kinetics were observed during fluvoxamine treatment. These findings indicate that, at the dosage tested, fluvoxamine markedly inhibits the demethylation of imipramine without affecting significantly the CYP2D6-mediated hydroxylation of desipramine.

引用

页码：243 / 246

页数：4

共 22 条

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