MERCURY TOXICOKINETICS IN WISTAR RATS EXPOSED TO ELEMENTAL MERCURY-VAPOR - MODELING AND COMPUTER-SIMULATION

被引：6

作者：

FALNOGA, I

MRHAR, A

KARBA, R

STEGNAR, P

SKREBLIN, M

TUSEKZNIDARIC, M

机构：

[1] UNIV LJUBLJANA,FAC NAT SCI & TECHNOL,DEPT PHARM,LJUBLJANA 61111,SLOVENIA

[2] UNIV LJUBLJANA,FAC ELECT & COMP ENGN,LJUBLJANA 61111,SLOVENIA

来源：

ARCHIVES OF TOXICOLOGY | 1994年 / 68卷 / 07期

关键词：

ELEMENTAL MERCURY VAPOR; RATS; TOXICOKINETICS; COMPARTMENTAL MODEL; COMPUTER SIMULATION;

D O I：

10.1007/s002040050090

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The kinetics of total mercury (Hg) absorption, distribution and elimination in Wistar rats exposed for long periods to elemental mercury vapour (Hg degrees) in the Idrija mercury mine were studied. From the experimental data base a compartmental model was built as a framework for experimental data interpretation and prediction of organ mercury levels under different conditions. Using the model the exposures of rats under conditions comparable to those of professionally exposed workers (mercury miners, workers in the chloralkali industry) and individuals with amalgam fillings were simulated.

引用

页码：406 / 415

页数：10