A HISTORY OF FRONTAL AND TEMPORAL-LOBE ASPECTS OF THE NEUROPHARMACOLOGY OF SCHIZOPHRENIA

被引:11
作者
KERWIN, R
机构
[1] INST PSYCHIAT, NEUROSCI, LONDON SE5, ENGLAND
[2] MAUDSLEY HOSP & INST PSYCHIAT, LONDON SE5 8AZ, ENGLAND
关键词
SCHIZOPHRENIA; FRONTAL CORTEX; MEDIAL TEMPORAL LOBE; NEUROCHEMISTRY; REVIEW;
D O I
10.1177/026988119200600217
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In the past two decades neurobiological research into schizophrenia has seen a shift of emphasis from the dopaminergic pharmacology of subcortical systems to areas of abnormality inferred from direct studies, i.e. frontal cortex and medial temporal lobe. Recent research has tried to integrate morphological abnormalities with neurochemical and pharmacological data. These integrated approaches have uncovered neurochemical systems other than dopamine which are of importance. This approach has led to greater understanding of neurochemical mechanisms associated with these abnormalities and may provide novel approaches for therapeutic intervention.
引用
收藏
页码:230 / 240
页数:11
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