CL(-)CHANNELS ARE RANDOMLY ACTIVATED BY CONTINUOUS GABA SECRETION IN CULTURED EMBRYONIC RAT HIPPOCAMPAL-NEURONS

被引：49

作者：

VALEYEV, AY ^{[1
]}

CRUCIANI, RA ^{[1
]}

LANGE, GD ^{[1
]}

SMALLWOOD, VS ^{[1
]}

BARKER, JL ^{[1
]}

机构：

[1] NINCDS,INSTRUMENTATE COMP SECT,BETHESDA,MD 20892

来源：

NEUROSCIENCE LETTERS | 1993年 / 155卷 / 02期

关键词：

GABA; SECRETION; GABA-A RECEPTOR; BICUCULLINE; EMBRYONIC HIPPOCAMPAL NEURON;

D O I：

10.1016/0304-3940(93)90707-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Throughout the adult vertebrate central nervous system (CNS) gamma-aminobutyric acid (GABA) mediates transient Cl- conductances commonly identified as fast, Cl--dependent inhibitory synaptic signals [Prog. Neurobiol., 36 (1991) 35 92]. In the rat hippocampus Cl--dependent excitatory transients mediated by GABA emerge during the first postnatal week superimposed on a steady-state baseline that is also Cl-- and GABA-dependent [Int. J.Dev. Neurosci., 8 (1990) 481-490]. Here we report that many embryonic rat hippocampal neurons cultured for hours to days exhibit random fluctuations in Cl- channel activity that are mediated by continuous secretion of GABA in the absence of transients. Thus, GABA is broadcast tonically before it is released transiently.

引用

页码：199 / 203

页数：5

共 18 条

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