AMMONIA STIMULATES THE RELEASE OF TAURINE FROM CULTURED ASTROCYTES

被引：29

作者：

ALBRECHT, J

BENDER, AS

NORENBERG, MD

机构：

[1] UNIV MIAMI,SCH MED,DEPT PATHOL,NEUROPATHOL LAB,MIAMI,FL 33101

[2] VET ADM MED CTR,MIAMI,FL 33101

[3] POLISH ACAD SCI,MED RES CTR,DEPT NEUROPATHOL,PL-00784 WARSAW,POLAND

来源：

BRAIN RESEARCH | 1994年 / 660卷 / 02期

关键词：

AMINO ACID RELEASE; AMMONIUM CHLORIDE; ASTROCYTES; GABA; GLUTAMATE; HEPATIC ENCEPHALOPATHY; TAURINE;

D O I：

10.1016/0006-8993(94)91301-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of ammonia on the release of the neuroactive amino acids taurine (TAU), gamma-aminobutyric acid (GABA) and D-aspartate (D-ASP), an analog of L-glutamate (L-GLU), from cultured rat cortical astrocytes was studied. NH4Cl (1 and 5 mM) induced the release of TAU. TAU release was reduced when Na+ was removed, and was almost completely abolished when Cl- was omitted. In contrast, TAU basal release was enhanced upon removal of Na+ or Cl-. Ammonia inhibited the release of GABA and D-ASP. Ammonia-induced release of astroglial TAU may modify the neuronal excitability accompanying hyperammonemic conditions.

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收藏

页码：288 / 292

页数：5

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