A PHENOXY-BRIDGED HOMODINUCLEAR ZN COMPLEX WITH AN UNUSUAL COORDINATION SPHERE - MODEL-COMPOUND FOR THE ACTIVE-SITE OF PHOSPHOLIPASE-C

被引：87

作者：

UHLENBROCK, S ^{[1
]}

KREBS, B ^{[1
]}

机构：

[1] UNIV MUNSTER,INST ANORGAN CHEM,WILHELM KLEMM STR 8,W-4400 MUNSTER,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 12期

关键词：

D O I：

10.1002/anie.199216471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The imitation of not only the structure but also the function of the active site of the metalloenzyme phospholipase C seems to have been achieved with complex 1 (O(w) = OH2). The two Zn atoms in 1 are bridged by a phenoxy and a carboxylate group. In addition, one Zn atom binds an H2O molecule, which is important for the catalytic process. [Zn2(bbap)H2O(mu-OBz)]2+ 1 Hbbap = bis[bis(benzimidazolylmethyl)aminomethyl]methylphenol

引用

页码：1647 / 1648

页数：2

共 26 条

[11] Dixon N. E., 1983, ZINC ENZYMES, P253
[12] SYNTHESIS AND STRUCTURE OF DIMERIC METAL-COMPLEXES WITH N(3)/N(9)-CHELATING HYPOXANTHINE LIGANDS AND WITH BRIDGING WATER-MOLECULES - [M2(MU-HYXAN)2(SO4)2(MU-H2O)2(H2O)2] (M = CU, CD, ZN, HYXAN = HYPOXANTHINE)
DUBLER, E
HANGGI, G
SCHMALLE, H
[J]. INORGANIC CHEMISTRY, 1990, 29 (13) : 2518 - 2523
[13] ZINC, 3,5-DIMETHYLPYRAZOLATE COMPLEXES - SYNTHESIS AND STRUCTURAL STUDIES - THE CRYSTAL AND MOLECULAR-STRUCTURE OF [ZN2(DMPZ)4(HDMPZ)2]
EHLERT, MK
RETTIG, SJ
STORR, A
THOMPSON, RC
TROTTER, J
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1990, 68 (09): : 1494 - 1498
[14] Frausto da Silva J.J.R., 1991, BIOL CHEM ELEMENTS
[15] GALDES A, 1983, ZINC ITS ROLE BIOL N, P1
[16] HIGH-RESOLUTION (1.5 A) CRYSTAL-STRUCTURE OF PHOSPHOLIPASE-C FROM BACILLUS-CEREUS
HOUGH, E
HANSEN, LK
BIRKNES, B
JYNGE, K
HANSEN, S
HORDVIK, A
LITTLE, C
DODSON, E
DEREWENDA, Z
[J]. NATURE, 1989, 338 (6213) : 357 - 360
[17] PENTACOORDINATE ZINC-COMPLEXES OF IMIDAZOLE NITROGEN DONORS AS STRUCTURAL MODELS FOR THE ACTIVE-SITE IN ENZYMES - PREPARATION AND CRYSTAL-STRUCTURES OF (MU-2,2'-BIIMIDAZOLE)TETRAKIS(2,2'-BIIMIDAZOLE)DIZINC(II) TETRAPERCHLORATE TRIHYDRATE AND BIS(2,2'-BIIMIDAZOLE) (FORMATO)ZINC(II) PERCHLORATE
KIRCHNER, C
KREBS, B
[J]. INORGANIC CHEMISTRY, 1987, 26 (21) : 3569 - 3576
[18] HISTIDINE RESIDUES OF PHOSPHOLIPASE-C FROM BACILLUS-CEREUS
LITTLE, C
[J]. BIOCHEMICAL JOURNAL, 1977, 167 (02) : 399 - 404
[19] ZINC PYRAZOLYLBORATE COMPLEXES RELEVANT TO THE BIOLOGICAL FUNCTION OF CARBONIC-ANHYDRASE
LOONEY, A
PARKIN, G
ALSFASSER, R
RUF, M
VAHRENKAMP, H
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1992, 31 (01): : 92 - 93
[20] LOONEY A, 1992, ANGEW CHEM, V104, P57

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