SYNTHESIS OF 10-DEACETOXYTAXOL AND 10-DEOXYTAXOTERE

被引：48

作者：

CHAUDHARY, AG ^{[1
]}

KINGSTON, DGI ^{[1
]}

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(00)74046-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

10-Deacetoxytaxol (9) and 10-deoxytaxotere (10) have been prepared from 10-deacetylbaccatin III by attachment of the C-13 side-chain and deoxygenation. 10-Deacetoxytaxol is comparable to taxol in its cytotoxicity to P-388 cells, but 10-deoxytaxotere is significantly more cytotoxic than taxol.

引用

页码：4921 / 4924

页数：4

共 28 条

[1] NEW AND SELECTIVE REACTIONS AND REAGENTS IN CARBOHYDRATE-CHEMISTRY
BARTON, DHR
MOTHERWELL, WB
[J]. PURE AND APPLIED CHEMISTRY, 1981, 53 (01) : 15 - 31
[2] BISSERY MC, 1991, CANCER RES, V51, P4845
[3] BLECHERT S, 1990, ALKALOIDS CHEM PHARM, V39, P195
[4] CHAUDHARY AG, 1993, IN PRESS J ORG CHEM, V58
[5] THE CHEMISTRY OF TAXANES - REACTION OF TAXOL AND BACCATIN DERIVATIVES WITH LEWIS-ACIDS IN APROTIC AND PROTIC MEDIA
CHEN, SH
HUANG, S
WEI, JM
FARINA, V
[J]. TETRAHEDRON, 1993, 49 (14) : 2805 - 2828
[6] TAXOL STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 10-DEOXYTAXOL
CHEN, SH
FAIRCHILD, C
MAMBER, SW
FARINA, V
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (11) : 2927 - 2928
[7] IMPROVED PROTECTION AND ESTERIFICATION OF A PRECURSOR OF THE TAXOTERE(R) AND TAXOL SIDE-CHAINS
COMMERCON, A
BEZARD, D
BERNARD, F
BOURZAT, JD
[J]. TETRAHEDRON LETTERS, 1992, 33 (36) : 5185 - 5188
[8] DIRECT, HIGHLY EFFICIENT SYNTHESIS FROM (S)-(+)-PHENYLGLYCINE OF THE TAXOL AND TAXOTERE SIDE-CHAINS
DENIS, JN
CORREA, A
GREENE, AE
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (24) : 6939 - 6942
[9] RELATIONSHIPS BETWEEN THE STRUCTURE OF TAXOL ANALOGS AND THEIR ANTIMITOTIC ACTIVITY
GUERITTEVOEGELEIN, F
GUENARD, D
LAVELLE, F
LEGOFF, MT
MANGATAL, L
POTIER, P
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) : 992 - 998
[10] MODERN METHODS FOR THE RADICAL DEOXYGENATION OF ALCOHOLS
HARTWIG, W
[J]. TETRAHEDRON, 1983, 39 (16) : 2609 - 2645

← 1 2 3 →