KINETIC ISOTOPE EFFECTS IN THE DEPROTONATION OF CHIRAL FORMAMIDINES

被引:13
作者
WARMUS, JS [1 ]
RODKIN, MA [1 ]
BARKLEY, R [1 ]
MEYERS, AI [1 ]
机构
[1] COLORADO STATE UNIV,DEPT CHEM,FT COLLINS,CO 80523
关键词
D O I
10.1039/c39930001357
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Metallation of 6,7-dimethoxy isoquinoline formamidines show a kinetic isotope effect, in contrast to the metallation of the 6,7-dihydro system; the isotope effect for the secondary proton in the dimethoxy system is smaller than usual (2.0) while the isotope effect for tertiary proton removal is somewhat larger (approximately 4.0), this is explained by the magnitude of pK(a) on isotope effect as well as competition between the pre-complexation step and the deprotonation step.
引用
收藏
页码:1357 / 1359
页数:3
相关论文
共 13 条