ANTIHYPERTENSIVE AGENTS - ANGIOTENSIN CONVERTING ENZYME-INHIBITORS - 1-[3-(ACYLTHIO)-3-AROYLPROPIONYL]-L-PROLINES

被引：29

作者：

MCEVOY, FJ ^{[1
]}

LAI, FM ^{[1
]}

ALBRIGHT, JD ^{[1
]}

机构：

[1] AMER CYANAMID CO,LEDERLE LABS,DIV MED RES,PEARL RIVER,NY 10965

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1983年 / 26卷 / 03期

关键词：

D O I：

10.1021/jm00357a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：381 / 394

页数：14

共 18 条

[1] USE OF ALPHA-(ARYL)-4-MORPHOLINEACETONITRILES (MASKED ACYL ANION EQUIVALENTS) IN 1,4-ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS AND NITRILES - VERSATILE SYNTHETIC ROUTE TO 6-ARYL-3(2H)PYRIDAZINONES [J].

ALBRIGHT, JD ;

MCEVOY, FJ ;

MORAN, DB .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1978, 15 (06) :881-892

[2] STUDIES ON THE MECHANISM OF CHUGAEV AND ACETATE THERMAL DECOMPOSITIONS .2. CIS-2-METHYL-1-TETRALOL AND TRANS-2-METHYL-1-TETRALOL [J].

ALEXANDER, ER ;

MUDRAK, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (07) :3194-3198

[3] CONVERTING ENZYME-INHIBITION WITH AN ORALLY ACTIVE COMPOUND IN HYPERTENSIVE MAN [J].

BRAVO, EL ;

TARAZI, RC .

HYPERTENSION, 1979, 1 (01) :39-46

[4] SPECTROPHOTOMETRIC ASSAY AND PROPERTIES OF ANGIOTENSIN-CONVERTING ENZYME OF RABBIT LUNG [J].

CUSHMAN, DW ;

CHEUNG, HS .

BIOCHEMICAL PHARMACOLOGY, 1971, 20 (07) :1637-+

[5]

HARNIK M, 1965, ISR J CHEM, V3, P7

[6]

LAI FM, 1980, J PHARMACOL EXP THER, V214, P388

[7]

LECLERC G, 1967, B SOC CHIM FR, P1302

[8] ALKYLATIONS AND ACYLATIONS OF ALPHA-ARYL-4-MORPHOLINEACETONITRILES (MASKED ACYL ANION EQUIVALENTS) AND THEIR USE IN 1,4-ADDITIONS [J].

MCEVOY, FJ ;

ALBRIGHT, JD .

JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (25) :4597-4603

[9] ANGIOTENSIN-CONVERTING ENZYME INHIBITORS FROM VENOM OF BOTHROPS-JARARACA ISOLATION, ELUCIDATION OF STRUCTURE, AND SYNTHESIS [J].

ONDETTI, MA ;

WILLIAMS, NJ ;

SABO, EF ;

PLUSCEC, J ;

WEAVER, ER ;

KOCY, O .

BIOCHEMISTRY, 1971, 10 (22) :4033-&

[10] DESIGN OF SPECIFIC INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME - NEW CLASS OF ORALLY ACTIVE ANTIHYPERTENSIVE AGENTS [J].

ONDETTI, MA ;

CUSHMAN, DW .

SCIENCE, 1977, 196 (4288) :441-444

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