ELECTRON-IMPACT AND FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRIC ANALYSIS OF THE FOOD-BORNE CARCINOGENS 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE, 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-F]QUINOXALINE AND THEIR METABOLITES

被引：7

作者：

FAY, LB

TURESKY, RJ

机构：

[1] Nestec Ltd, Nestlé Research Centre, Lausanne, 1000, Vers-chez-les-Blanc

来源：

BIOLOGICAL MASS SPECTROMETRY | 1992年 / 21卷 / 09期

关键词：

D O I：

10.1002/bms.1200210907

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Electron impact (EI) and fast atom bombardment (FAB) mass spectrometry were used to characterize the heterocyclic aromatic amines, 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and their metabolites. The carcinogenic N2-hydroxy metabolites and several non-conjugated detoxification products were analysed directly by EI mass spectrometry, while several polar sulphate and beta-glucuronic acid conjugates were analysed by FAB mass spectrometry. Analysis of beta-glucuronic acid conjugates was also achieved by EI mass spectrometry following silylation.

引用

收藏

页码：463 / 469

页数：7

相关论文

共 14 条

[1] CARCINOGENICITY OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE IN NONHUMAN-PRIMATES - INDUCTION OF TUMORS IN 3 MACAQUES [J].

ADAMSON, RH ;

THORGEIRSSON, UP ;

SNYDERWINE, EG ;

THORGEIRSSON, SS ;

REEVES, J ;

DALGARD, DW ;

TAKAYAMA, S ;

SUGIMURA, T .

JAPANESE JOURNAL OF CANCER RESEARCH, 1990, 81 (01) :10-14

[2] ANAEROBIC METABOLISM OF 2-AMINO-3-METHYL-3H-IMIDAZO[4,5-F]QUINOLINE (IQ) BY HUMAN FECAL FLORA [J].

BASHIR, M ;

KINGSTON, DGI ;

CARMAN, RJ ;

VANTASSELL, RL ;

WILKINS, TD .

MUTATION RESEARCH, 1987, 190 (03) :187-190

[3] IDENTIFICATION OF THE MUTAGENS IN COOKED BEEF [J].

FELTON, JS ;

KNIZE, MG ;

SHEN, NH ;

ANDRESEN, BD ;

BJELDANES, LF ;

HATCH, FT .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1986, 67 :17-24

[4] METABOLISM OF THE MUTAGEN MEIQX INVIVO - METABOLITE SCREENING BY LIQUID CHROMATOGRAPHY-THERMOSPRAY MASS-SPECTROMETRY [J].

GOODERHAM, NJ ;

WATSON, D ;

RICE, JC ;

MURRAY, S ;

TAYLOR, GW ;

DAVIES, DS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (03) :1377-1382

[5] N-HYDROXY-2-AMINOFLUORENE DERIVATIVES - CHEMICAL-REACTIVITY AND PRODUCT IDENTIFICATION BY MASS-SPECTROMETRY [J].

IORIO, MA ;

MAZZEOFARINA, A ;

SENECA, L ;

BONIFORTI, L .

BIOMEDICAL MASS SPECTROMETRY, 1985, 12 (01) :30-37

[6] ALTERATION OF URINARY LEVELS OF THE CARCINOGEN, N-HYDROXY-2-NAPHTHYLAMINE, AND ITS N-GLUCURONIDE IN THE RAT BY CONTROL OF URINARY PH, INHIBITION OF METABOLIC SULFATION, AND CHANGES IN BILIARY-EXCRETION [J].

KADLUBAR, FF ;

UNRUH, LE ;

FLAMMANG, TJ ;

SPARKS, D ;

MITCHUM, RK ;

MULDER, GJ .

CHEMICO-BIOLOGICAL INTERACTIONS, 1981, 33 (2-3) :129-147

[7] DETECTION AND MEASUREMENT OF MEIQX IN HUMAN-URINE AFTER INGESTION OF A COOKED MEAT MEAL [J].

MURRAY, S ;

GOODERHAM, NJ ;

BOOBIS, AR ;

DAVIES, DS .

CARCINOGENESIS, 1989, 10 (04) :763-765

[8] DISPOSITION AND METABOLISM OF THE FOOD MUTAGEN 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-F]QUINOXALINE (MEIQX) IN RATS [J].

SJODIN, P ;

WALLIN, H ;

ALEXANDER, J ;

JAGERSTAD, M .

CARCINOGENESIS, 1989, 10 (07) :1269-1275

[9]

SNYDERWINE E G, 1991, Proceedings of the American Association for Cancer Research Annual Meeting, V32, P121

[10] SUCCESSFUL USE OF SHORT-TERM TESTS FOR ACADEMIC PURPOSES - THEIR USE IN IDENTIFICATION OF NEW ENVIRONMENTAL CARCINOGENS WITH POSSIBLE RISK FOR HUMANS [J].

SUGIMURA, T .

MUTATION RESEARCH, 1988, 205 (1-4) :33-39