HOST-REACTION AGAINST ALGINATE-POLYLYSINE MICROCAPSULES CONTAINING LIVING CELLS

被引：23

作者：

VANDENBOSSCHE, GMR

BRACKE, ME

CUVELIER, CA

BORTIER, HE

MAREEL, MM

REMON, JP

机构：

[1] STATE UNIV GHENT,PHARMACEUT TECHNOL LAB,HARELBEKESTR 72,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT,EXPTL CANCEROL LAB,B-9000 GHENT,BELGIUM

[3] STATE UNIV GHENT,DEPT PATHOL,B-9000 GHENT,BELGIUM

[4] STATE UNIV GHENT,EMBRYOL LAB,B-9000 GHENT,BELGIUM

[5] STATE UNIV GHENT HOSP,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 02期

关键词：

D O I：

10.1111/j.2042-7158.1993.tb03695.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Syngeneic and nude mice were injected intraperitoneally with saline, empty microcapsules, aggregates of tumourogenic MO4 cells, encapsulated non-tumourogenic MO cells and encapsulated MO4 cells. The host reaction 4 days after injection, was evaluated by counting the leucocytes in the peritoneal cavity and the cells sticking to recovered microcapsules. A significantly lower number of peritoneal leucocytes was found in mice injected with empty microcapsules or encapsulated MO cells as compared with encapsulated MO4 cells. Histological evaluation showed a significantly higher number of cells sticking to microcapsules containing cells as compared with empty microcapsules. These observations showed that the cellular host reaction against intraperitoneal implants can be evaluated by counting the leucocytes in the peritoneal lavage and histology of recovered capsules.

引用

页码：121 / 125

页数：5

共 46 条

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