THE CONSERVATION OF NEUROTROPHIC FACTORS DURING VERTEBRATE EVOLUTION

被引：44

作者：

GOTZ, R

SCHARTL, M

机构：

[1] UNIV WURZBURG,BIOZENTRUM,PHYSIOL CHEM ABT 1,D-97074 WURZBURG,GERMANY

[2] MAX PLANCK INST PSYCHIAT,DEPT NEUROCHEM,D-82152 MARTINSRIED,GERMANY

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1994年 / 108卷 / 01期

关键词：

NEUROTROPHIC FACTORS; VERTEBRATE EVOLUTION;

D O I：

10.1016/1367-8280(94)90082-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotrophic factors are a family of extracellular ligands that affect the differentiation, survival (by inhibition of apoptosis) and maintenance of function of neuronal cells in vertebrates. The family includes nerve growth factor (N6F), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). The survival specificities of NGF and BDNF for different classes of chick neurons are maintained from the fish to the mammalian proteins, implying a conserved interaction with neuronal cell surface receptors (of the Trk family). However, the quantitative effect of a fish neurotrophin can differ significantly from that of the mammalian orthologue.

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页码：1 / 10

页数：10

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