THE CONSERVATION OF NEUROTROPHIC FACTORS DURING VERTEBRATE EVOLUTION

被引：44

作者：

GOTZ, R

SCHARTL, M

机构：

[1] UNIV WURZBURG,BIOZENTRUM,PHYSIOL CHEM ABT 1,D-97074 WURZBURG,GERMANY

[2] MAX PLANCK INST PSYCHIAT,DEPT NEUROCHEM,D-82152 MARTINSRIED,GERMANY

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1994年 / 108卷 / 01期

关键词：

NEUROTROPHIC FACTORS; VERTEBRATE EVOLUTION;

D O I：

10.1016/1367-8280(94)90082-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotrophic factors are a family of extracellular ligands that affect the differentiation, survival (by inhibition of apoptosis) and maintenance of function of neuronal cells in vertebrates. The family includes nerve growth factor (N6F), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). The survival specificities of NGF and BDNF for different classes of chick neurons are maintained from the fish to the mammalian proteins, implying a conserved interaction with neuronal cell surface receptors (of the Trk family). However, the quantitative effect of a fish neurotrophin can differ significantly from that of the mammalian orthologue.

引用

收藏

页码：1 / 10

页数：10

相关论文

共 107 条

[51] PATTERNING THE BRAIN OF THE ZEBRAFISH EMBRYO [J].

KIMMEL, CB .

ANNUAL REVIEW OF NEUROSCIENCE, 1993, 16 :707-732

[52] PROMOTION OF CENTRAL CHOLINERGIC AND DOPAMINERGIC NEURON DIFFERENTIATION BY BRAIN-DERIVED NEUROTROPHIC FACTOR BUT NOT NEUROTROPHIN 3 [J].

KNUSEL, B ;

WINSLOW, JW ;

ROSENTHAL, A ;

BURTON, LE ;

SEID, DP ;

NIKOLICS, K ;

HEFTI, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (03) :961-965

[53] COEXPRESSION OF NEUROTROPHINS AND THEIR RECEPTORS IN NEURONS OF THE CENTRAL-NERVOUS-SYSTEM [J].

KOKAIA, Z ;

BENGZON, J ;

METSIS, M ;

KOKAIA, M ;

PERSSON, H ;

LINDVALL, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6711-6715

[54] EVIDENCE THAT BRAIN-DERIVED NEUROTROPHIC FACTOR IS A TROPHIC FACTOR FOR MOTOR NEURONS INVIVO [J].

KOLIATSOS, VE ;

CLATTERBUCK, RE ;

WINSLOW, JW ;

CAYOUETTE, MH ;

PRICE, DL .

NEURON, 1993, 10 (03) :359-367

[55] NERVE GROWTH-FACTOR IN SYMPATHETIC-GANGLIA AND CORRESPONDING TARGET ORGANS OF THE RAT - CORRELATION WITH DENSITY OF SYMPATHETIC INNERVATION [J].

KORSCHING, S ;

THOENEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (11) :3513-3516

[56] TARGETED MUTATION OF THE GENE ENCODING THE LOW AFFINITY NGF RECEPTOR P75 LEADS TO DEFICITS IN THE PERIPHERAL SENSORY NERVOUS-SYSTEM [J].

LEE, KF ;

LI, E ;

HUBER, LJ ;

LANDIS, SC ;

SHARPE, AH ;

CHAO, MV ;

JAENISCH, R .

CELL, 1992, 69 (05) :737-749

[57] MOLECULAR-CLONING AND EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR [J].

LEIBROCK, J ;

LOTTSPEICH, F ;

HOHN, A ;

HOFER, M ;

HENGERER, B ;

MASIAKOWSKI, P ;

THOENEN, H ;

BARDE, YA .

NATURE, 1989, 341 (6238) :149-152

[58] ESSENTIAL ROLE OF NERVE GROWTH FACTOR IN SURVIVAL AND MAINTENANCE OF DISSOCIATED SENSORY AND SYMPATHETIC EMBRYONIC NERVE CELLS IN VITRO [J].

LEVIMONTALCINI, R ;

ANGELETTI, PU .

DEVELOPMENTAL BIOLOGY, 1963, 7 (01) :653-&

[59] DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN [J].

LEVIMONTALCINI, R ;

BOOKER, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1960, 46 (03) :384-391

[60] THE NERVE GROWTH-FACTOR 35 YEARS LATER [J].

LEVIMONTALCINI, R .

SCIENCE, 1987, 237 (4819) :1154-1162

← 1 2 3 4 5 6 7 8 9 10 →