ATTEMPTED RESOLUTION OF FREE (+/-)-CHLOROPHENYLISOPROPYLPHOSPHINE

被引：37

作者：

PABEL, M ^{[1
]}

WILLIS, AC ^{[1
]}

WILD, SB ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,INST ADV STUDIES,RES SCH CHEM,CANBERRA,ACT 0200,AUSTRALIA

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 09期

关键词：

D O I：

10.1016/0957-4166(95)00314-F

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(+/-)-Chlorophenylisopropylphosphine has been resolved in a palladium(II) complex containing the phosphine and ortho-metalated (R)-1-[1-(dimethylamino)ethyl]naphthalene; the configurationally homogeneous (R,Rp) diastereomer of the complex crystallises from the reaction mixture by typical second-order asymmetric transformation in overall 82% yield. The absolute configuration of the complex was determined by X-ray crystallography. The pure (R,Rp) diastereomer of the complex reacts quantitatively with methanol in the presence of triethylamine to give the corresponding methoxyphosphine complex with complete stereoselectivity and inversion at phosphorus. All attempts at liberating optically active chlorophosphine from the palladium complex were unsuccessful.

引用

页码：2369 / 2374

页数：6

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