INTEGRATED GENETIC-MAP OF HUMAN-CHROMOSOME-2

被引：8

作者：

COX, S

BRYANT, SP

COLLINS, A

WEISSENBACH, J

DONISKELLER, H

KOELEMAN, BPC

STEINKASSERER, A

SPURR, NK

机构：

[1] IMPERIAL CANC RES FUND,HUMAN GENET RESOURCES LAB,POTTERS BAR EN6 3LD,HERTS,ENGLAND

[2] PRINCESS ANNE HOSP,DEPT CHILD HLTH,CRC,GENET EPIDEMIOL RES GRP,SOUTHAMPTON SO9 4HA,HANTS,ENGLAND

[3] GENETHON,F-9100 EVRY,FRANCE

[4] WASHINGTON UNIV,SCH MED,DEPT SURG,DIV MOLEC GENET,ST LOUIS,MO 63110

[5] LEIDEN UNIV HOSP,HAEMOSTASIS & THROMBOSIS RES CTR,LEIDEN,NETHERLANDS

[6] UNIV OXFORD,DEPT BIOCHEM,MRC,IMMUNOCHEM UNIT,OXFORD OX1 3QU,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1995年 / 59卷

关键词：

D O I：

10.1111/j.1469-1809.1995.tb00760.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A framework genetic map of human chromosome 2 is described, integrating data from the Centre d'Etude du Polymorphisme Humain (CEPH) version 6 database, the CEPH chromosome 2 consortium database, the National Institute of Health (NIH)/CEPH Collaborative Mapping group and other laboratories. A comprehensive map is also presented, showing regional locations of a large number of additional loci. The framework map is used to identify an informative set of meiotic breakpoints within the CEPH families, and the utility of this information for mapping new markers is discussed. The degree of typing error within the data set is estimated, as are the sex-specific interference parameters. A location database for these genetic and additional cytogenetic data is constructed using algorithms which map genetic distances on to a physical scale, and the potential for this approach to aid the integration of genetic and physical data is examined.

引用

页码：413 / 434

页数：22

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