TUMOR-NECROSIS-FACTOR-ALPHA AND ENDOTOXIN INDUCE LESS PROSTAGLANDIN-E2 PRODUCTION FROM HYPOTHALAMI OF RATS FED COCONUT OIL THAN FROM HYPOTHALAMI OF RATS FED MAIZE OIL

被引:6
作者
BIBBY, DC [1 ]
GRIMBLE, RF [1 ]
机构
[1] SOUTHAMPTON UNIV,SCH MED,DEPT HUMAN NUTR,SOUTHAMPTON SO9 3TU,ENGLAND
关键词
fats; prostaglandins; tumour necrosis factor;
D O I
10.1042/cs0790657
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The primary aim of the study was to determine whether the stimulatory effect of tumour necrosis factor α and endotoxin on hypothalamic prostaglandin E2 production was influenced by dietary fats containing different amounts of linoleic acid. Rats received diets containing 20% (w/w) maize oil or 19% (w/w) coconut oil plus 1% (w/w) maize oil for 8 weeks. A subsidiary part of the study examined the effect of tumour necrosis factor-α on the ability of the calcium ionophore A23187 to stimulate prostaglandin E2 and leukotriene C4 production by hypothalami from chow-fed rats. While tumour necrosis factor-α enhanced prostaglandin E2 production in response to A23187, neither agent had an effect on leukotriene C4 production. Hypothalami from rats fed maize oil exhibited increased prostaglandin E2 production in response to both pyrogens. This did not occur with hypothalami from rats fed coconut oil. Coconut oil might exert its modulatory effect by bringing about a reduction in membrane phospholipid arachidonic acid content.
引用
收藏
页码:657 / 662
页数:6
相关论文
共 39 条
  • [11] FORMATION OF LEUKOTRIENE-C4-LIKE MATERIAL BY RAT-BRAIN TISSUE
    DEMBINSKAKIEC, A
    SIMMET, T
    PESKAR, BA
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 99 (01) : 57 - 62
  • [12] TUMOR-NECROSIS-FACTOR (CACHECTIN) IS AN ENDOGENOUS PYROGEN AND INDUCES PRODUCTION OF INTERLEUKIN-1
    DINARELLO, CA
    CANNON, JG
    WOLFF, SM
    BERNHEIM, HA
    BEUTLER, B
    CERAMI, A
    FIGARI, IS
    PALLADINO, MA
    OCONNOR, JV
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (06) : 1433 - 1450
  • [13] DINARELLO CA, 1988, REV INFECT DIS, V10, P163
  • [14] ENDRES S, 1989, NEW ENGL J MED, V320, P266
  • [15] GERMAN JB, 1987, PROSTAG LEUKOTR ESS, V30, P69
  • [16] ACTIVATION OF PROTEIN BREAKDOWN AND PROSTAGLANDIN-E2 PRODUCTION IN RAT SKELETAL-MUSCLE IN FEVER IS SIGNALED BY A MACROPHAGE PRODUCT DISTINCT FROM INTERLEUKIN-1 OR OTHER KNOWN MONOKINES
    GOLDBERG, AL
    KETTELHUT, IC
    FURUNO, K
    FAGAN, JM
    BARACOS, V
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (05) : 1378 - 1383
  • [17] FEVER AND AGING - CENTRAL-NERVOUS-SYSTEM PROSTAGLANDIN-E2 IN RESPONSE TO ENDOTOXIN
    GRAHN, D
    NORMAN, DC
    YOSHIKAWA, TT
    [J]. EXPERIMENTAL GERONTOLOGY, 1987, 22 (04) : 249 - 255
  • [18] EFFECTS OF DIETARY CORN-OIL AND SALMON OIL ON LIPIDS AND PROSTAGLANDIN-E2 IN RAT GASTRIC-MUCOSA
    GRATAROLI, R
    LEONARDI, J
    CHARBONNIER, M
    LAFONT, R
    LAFONT, H
    NALBONE, G
    [J]. LIPIDS, 1988, 23 (07) : 666 - 670
  • [19] HELFGOTT DC, 1989, J IMMUNOL, V142, P948
  • [20] DUODENAL MUCOSA SYNTHESIS OF PROSTAGLANDINS IN DUODENAL-ULCER DISEASE
    HILLIER, K
    SMITH, CL
    JEWELL, R
    ARTHUR, MJP
    ROSS, G
    [J]. GUT, 1985, 26 (03) : 237 - 240