NOVEL ANTITUMOR ANTIBIOTICS, SAPTOMYCINS .2. ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

被引：29

作者：

ABE, N

ENOKI, N

NAKAKITA, Y

UCHIDA, H

NAKAMURA, T

MUNEKATA, M

机构：

[1] Pharmaceutical Research Laboratories, Sapporo Breweries, Ltd., Shizuoka 425, 10 Okathome, Yaizu

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 10期

关键词：

D O I：

10.7164/antibiotics.46.1536

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A complex of novel antitumor antibiotics related to the pluramycin-group was isolated from the fermentation of actinomycete, named Streptomyces sp. HP530. The producing strain mutated frequently. The products isolated from the parent strain were designated saptomycins A, B, C1, C2 and F, while those of the mutant were named saptomycins D, E, G and H. These structures were elucidated by several NMR spectral analyses and other spectroscopic experiments.

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页码：1536 / 1549

页数：14

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