THE SYNTHESIS OF A CONFORMATIONALLY RESTRAINED, COMBINED THROMBOXANE ANTAGONIST/SYNTHASE INHIBITOR USING AN INTRAMOLECULAR STILLE-PALLADIUM-CATALYZED OR GRIGG-PALLADIUM-CATALYZED CYCLIZATION STRATEGY

被引：22

作者：

FINCH, H

PEGG, NA

EVANS, B

机构：

[1] Department of Medicinal Chemistry, Glaxo Group Research Ltd., Ware

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(00)61429-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the conformationally restrained analogues 15 and 20, of the combined thromboxane antagonist / synthase inhibitor GR85305, has been achieved using novel intramolecular 'Stille'- and/or 'Grigg'-palladium-catalysed cyclisation reactions. A novel free radical cyclisation leading to an eight-membered ring is also described

引用

页码：8353 / 8356

页数：4

共 26 条

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