CGRP ANTAGONISTS ENHANCE GASTRIC-ACID SECRETION IN 2-H PYLORUS-LIGATED RATS

被引：23

作者：

KATO, K

MARTINEZ, V

STPIERRE, S

TACHE, Y

机构：

[1] UNIV CALIF LOS ANGELES, W LOS ANGELES VET AFFAIRS MED CTR, CTR ULCER RES & EDUC, LOS ANGELES, CA 90073 USA

[2] UNIV CALIF LOS ANGELES, DEPT MED, LOS ANGELES, CA 90073 USA

[3] UNIV CALIF LOS ANGELES, BRAIN RES INST, LOS ANGELES, CA 90073 USA

[4] UNIV QUEBEC, INST NATL RECH SCI SANTE, POINTE CLAIRE, PQ H9R 1G6, CANADA

来源：

PEPTIDES | 1995年 / 16卷 / 07期

关键词：

CGRP; CGRP(8-37); CGRP ANTIBODY; GASTRIC ACID SECRETION; PYLORUS LIGATION; PENTAGASTRIN;

D O I：

10.1016/0196-9781(95)02004-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of calcitonin gene-related peptide (CGRP) antagonists on gastric acid secretion was investigated in rats. Intravenous injection of the CGRP receptor antagonist, CGRP(8-37)(128 nmol/kg) or the CGRP antibody #4901 (4.8 mg/kg, IV) completely prevented alpha-CGRP (3.9 nmol/kg/h)-induced inhibition of acid response to pentagastrin in urethane-anesthetized rats with gastric fistula. CGRP antibody (4.8 mg/kg, IV) increased by 93% gastric acid secretion in conscious rats with pylorus ligation for 2 h. CGRP(8-37) (128 nmol/kg, IV) also enhanced the acid response measured 2 h after pylorus ligation in conscious rats and in urethane-anesthetized rats infused with pentagastrin by 91% and 56%, respectively. These results suggest that endogenous CGRP attenuates the gastric acid response measured 2 h after pylorus ligation.

引用

页码：1257 / 1262

页数：6

共 38 条

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